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E-Journal of Chemistry
Volume 9 (2012), Issue 1, Pages 21-26

Conductometric Study of Nimesulide in Aqueous Solutions of Hydrotropic Agents at Different Temperatures

Chandravir S. Solanki,1 Paresh Mishra,1 Mahesh Kumar Talari,2 Minaketan Tripathy,3 and Upendra N. Dash4

1Indira Gandhi Institute of Pharmaceutical Sciences, Nayapalli, Bhubaneswar, India
2Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), Shah Alam, Selangor, 40450, Malaysia
3Faculty of Pharmacy, Universiti Teknologi MARA (UiTM), Campus Puncak Alam, Selangor, 42300, Malaysia
4Department of Chemistry, ITER, Siksha ‘O’ Anusandhan University, Bhubanesawr, 751030, India

Received 4 August 2010; Revised 20 October 2010; Accepted 28 December 2010

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Conductance values of nimesulide have been determined in water in 0.1, 0.2, 0.4, 0.6, 0.8, 1 and 2 mol dm-3 aqueous solutions of hydrotropic agents (sodium benzoate, sodium salicylate, sodium bromide and nicotinamide) at temperatures 298.15, 303.15, 308.15 and 313.15 K. The conductance values have been used to evaluate the limiting molar conductance and association constants by means of Shedlovsky extrapolation technique. Thermodynamic parameters for the association process of nimesulide in aqueous solutions of hydrotropic agents have also been calculated.