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E-Journal of Chemistry
Volume 9, Issue 3, Pages 1412-1421

Kinetic Determination of Paracetamol using a Novel Belousov-Zhabotinskii Oscillating System Catalyzed by a Tetraazamacrocyclic Complex

1Department of Chemistry, Anhui University, No. 3 Feixi Road, Hefei, Anhui, 230039, China
2Institute of Applied Chemistry, East China Jiaotong University, Nanchang 330013, China

Received 20 September 2011; Accepted 8 November 2011

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A new analytical method for determination of paracetamol is proposed. This method is based on a novel B-Z oscillating system, which involves a Tetraazamacrocyclic Complex [CuL](ClO4)2 as catalyst and malic acid as the substrate. The ligand L in the complex is 5,7,7,12,14,14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene. By perturbation mount of paracetamol on the B-Z system, there is a linear relationship between the changes in the oscillation amplitude and the logarithm of paracetamol concentration in the range 5×10-7 to 2×10-4 M, with a correlation coefficient of 0.99743. The effects of influential variables, such as the concentration of reaction components, temperature and on the determinations were studied. The probable mechanism involving the perturbation of paracetamol on the oscillating chemical system was also discussed.