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Platinum(II) Complexes with Tetradentate Schiff Bases as Ligands: Synthesis, Characterization and Detection of DNA Interaction by Differential Pulse Voltammetry
Lijun Li
,1 Chao Tian,1 Cheng Wang,1 Guangyuan Wang,1 Lianzeng Wang,1 and Jianlong Du11College of Chemistry & Environmental Science Chemical Biology Key Laboratory of Hebei Province, Hebei University, Baoding 071002, China
Abstract
Five sterically hindered platinum(II) complexes with tetradentate schiff bases as ligands, [Pt(L)] (L= N,N′-bisalicylidene-1,2-ethylenediamine (L1), N,N′-bisalicylidene-1,2-cyclohexanediamine (L2), N,N′-bis(5-hydroxyl-salicylidene)-1,2-cyclohexanediamine (L3), N,N′-bisalicylidene-1,2-diphenyl-ethylenediamine (L4) and N,N′-bis(3-tert-butyl-5-methyl-salicylidene)-1,2-diphenylethylenediamine (L5) ) have been synthesized and characterized by IR spectroscopy and elemental analysis. The sterical hindrance of antitumor drug candidates potentially makes them less susceptible to deactivation by sulphur containing proteins and helping to overcome resistance mechanisms. The interaction of these metal complexes with fish sperm single-stranded DNA (ssDNA) was studied electrochemically based on the oxidation signals of guanine and adenine. Differential pulse voltammetry was employed to monitor the DNA interaction in solution by using renewable pencil graphite electrode. The results indicate that ligands with different groups can strongly affect the interaction between [Pt(L)] complexes and ssDNA due to sterical hindrances and complex [Pt(L1)] has the best interaction with DNA among the five complexes.
Copyright
Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
