Journal of Chemistry

Journal of Chemistry / 2012 / Article

Open Access

Volume 9 |Article ID 757916 | https://doi.org/10.1155/2012/757916

J. Sudhakar Reddy, MD. S. Maqsood Ahmed, I. E. Chakravarthy, K. Prabhavathi, "Spectrophotometric Determination of Zidovudine in Pharmaceutical Dosage Forms", Journal of Chemistry, vol. 9, Article ID 757916, 4 pages, 2012. https://doi.org/10.1155/2012/757916

Spectrophotometric Determination of Zidovudine in Pharmaceutical Dosage Forms

Received13 May 2011
Accepted31 Jul 2011

Abstract

A simple, sensitive and economical spectrophotometric method has been developed for the determination of zidovudine in commercial dosage forms. The method was based on the formation of chloroform extractable complex of zidovudine with wool fast blue. The absorbance of the extractable ion pair complex is measured at the wavelength of maximum absorbance 590 nm against the reagent blank treated similarly. Statistical analysis proves that the proposed methods are reproducible and selective for the estimation of zidovudine in bulk drug and in its tablet dosage form.

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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