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E-Journal of Chemistry
Volume 9 (2012), Issue 4, Pages 2079-2088

Synthesis and Evaluation of Some Coumarin Based Schiff's Bases as Potential Antimicrobial Agents'

Department of Pharmaceutical Chemistry, PDEA's Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune–412301, India

Received 30 August 2011; Accepted 28 October 2011

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A series of the title compounds 3-(4-(4, 5-dihydro-5-(substituted phenyl)-1H-3-pyrazolyl) phenylimino) methyl)-4-chloro-2H-chromen-2-one 5(a-g) have been synthesized. These compounds were characterized on the basis of their spectral (IR, 1H NMR) data and evaluated for antimicrobial activity in vitro against gram positive bacteria, gram negative bacteria and fungi. The compound (5b) was found to be the most active with MIC of 20 µg/ml against all the tested organisms.