Table of Contents Author Guidelines Submit a Manuscript
E-Journal of Chemistry
Volume 9, Issue 4, Pages 2155-2165
http://dx.doi.org/10.1155/2012/857514

Synthesis of 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)acetamide Based Thiazolidinone Derivatives as Potent Antibacterial and Antifungal Agents

1Division of Pharmaceutical Chemistry, Department of Pharmacy, IEC College of Engineering & Technology, Knowledge Park-I, Greater Noida-201306, India
2Department of Pharmaceutical Technology, Meerut Institute of Engineering & Technology, Meerut-250005, India
3Maharaja Surajmal Institute of Pharmacy, Janak Puri, New Delhi-110058, India
4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi-110062, India
5Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ferozpur Road, Moga-142001, India

Received 17 November 2011; Accepted 15 January 2012

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Twelve compounds belonging to series 2-(3-methyl-2-oxoquinoxalin-1(2H)-yl)-N-[4-oxo-2-(substituted)phenyl-1,3-thiazolidin-3-yl]acetamide (5a-l) were synthesized. These compounds were evaluated for their in-vitro antibacterial against E. coli, S. aureus, K. pneumoniae, P. aeruginosa & antifungal activity against C. albicans, A. niger & A. flavus by cup-plate method. Structures of all the newly synthesized compounds were confirmed by elemental analysis, 1H-NMR & FT-IR spectral data interpretation. Compounds 5d & 5h having p-nitrophenyl & p-trifluoromethylphenyl group respectively on 2-position of thiazolidinone ring attached to N-atom of acetamido group on 1-position of 3-methyl-1H-quinoxaline-2-one, were found to be active against all the bacterial & fungal strains under investigation, while compound 5l having p-chlorophenyl on 2-position of thiazolidinone nucleus was reported as least active compound against all bacterial & fungal strain under investigation.