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E-Journal of Chemistry
Volume 9 (2012), Issue 1, Pages 318-322
http://dx.doi.org/10.1155/2012/902784

Synthesis and Antimicrobial Activity of Some New 1, 4-Benzothiazine Containing Thiosemicarbazides and 1, 3, 4-Oxadiazole Derivatives

Bhikan J Khairnar, Rahul S. Salunke, Premchand B. Patil, Sanjay A . Patil, Rajeshwar J . Kapade, Pravin S. Girase, and Bhata R. Chaudhari

Department of Chemistry, JET’s Z.B. Patil College, Dhule-424 002, India

Received 24 May 2011; Accepted 31 July 2011

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A series of novel 3- methyl-7-substituted-4H,4-benzothiazine-2-carbohydrazide (3a-e) and corresponding thiosemicarbazides (4-a-q); 2-[3-methyl-7-substituted- 4H -1, 4-benzothiazine-2-yl]-N-(aryl) hydrazine carbothiamide have been synthesized. The thiosemicarbazide when cyclized with iodine via intramolecular cyclisation gave benzothiazonyl oxadiazoles (5-a-q); 5-(3-methyl -7-substitued-4H- 1,4-benzothiazin-2-yl)- N —aryl- 1,3,4- oxadiazol -2-amine and the compounds were tested for antibacterial and antifungal activities against different microorganisms.