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E-Journal of Chemistry
Volume 9 (2012), Issue 4, Pages 2493-2500
http://dx.doi.org/10.1155/2012/953564

Synthesis and Evaluation of Some Coumarin Containing Potential Antimicrobial Agents

Department of Pharmaceutical Chemistry, Pdea's Seth Govind Raghunath, Sable College of Pharmacy, Saswad, Pune-412301, India

Received 20 August 2011; Accepted 4 October 2011

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A series of the Schiff’s bases incorporating coumarin and chalcone moeities, 3-(4-(4-(substituted phenyl)prop-1-ene-3-one) phenylimino) methyl)-4-chloro-2h-chromen-2-one 4(a-g) were synthesized as potential antimicrobial agents. These compounds were characterized on the basis of their spectral (IR, 1H NMR) data and evaluated for antimicrobial activity in vitro against gram positive and gram negative bacteria and fungi. Compound 4b was found to be most active with an MIC of 20 µg/mL against all the tested organisms.