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Journal of Chemistry
Volume 2013, Article ID 106734, 6 pages
http://dx.doi.org/10.1155/2013/106734
Research Article

Synthesis and Antimicrobial Activities of Some New Synthesized Imide and Schiff's Base Derivatives

1Chemistry Department, Girls College of Science, King Khalid University, Abha 9004, Saudi Arabia
2Applied Organic Chemistry Department, National Research Center, Dokki, Cairo 12622, Egypt
3Photochemistry Department, National Research Center, Dokki, Cairo 12622, Egypt
4Pharmaceutical Chemistry Department, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
5Drug Exploration & Development Chair, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

Received 18 January 2012; Accepted 16 April 2012

Academic Editor: Patricia E. Allegretti

Copyright © 2013 Nermien M. Sabry et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A series of 2,6-bis(substituted thiazolopyrimi-dinyl) pyridine (2a,b) and corresponding Schiff's bases (3a–j) were synthesized from 2,6-bis-(3-amino-2-methyl-4-oxo-9-substituted-3,4-dihydropyrido-[30,20 : 4,5]-thieno[3,2-d]pyrimidin-7-yl)pyridines (1a,b) as starting materials. The compounds 1a,b were reacted with 2,3,4,5-tetrachlorophthalic anhydride in glacial acetic acid to give the corresponding bis-imides (2a,b). But they are treated with aromatic aldehydes in refluxing ethanol to afford the Schiff’s base derivatives (3a–j). The antimicrobial screening showed that many of these newly synthesized compounds had good antimicrobial activities comparable to streptomycin and fusidic acid as positive controls. The detailed synthesis, spectroscopic data, and antimicrobial activities of the synthesized compounds were reported.