Research Article

“On Water” Sonochemical Multicomponent Synthesis of Novel Bioactive 1,1′-(Aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) Di(alkanoates and benzoates)

Table 2

Synthesis of 1,1′-(aryl)bis(2-(cyclohexylamino)-2-oxoethane-1,1-diyl) di (alkanoates and benzoates) under ultrasound irradiation and antimicrobial activity of the products (zone of inhibition in mm).

EntryProductsMP (°C)Time (min)Yield (%)a,bB.  subtilis P.  aeruginosa A. bacter

a125959.tab.002a212–2144909 (11)c (10)d14 (14)c (15)d5 (7)c

b125959.tab.002b232-2334958 (8)c (9)d12 (13)c (12)d3

c125959.tab.002c212–214590412 (11)c4

d125959.tab.002d214-2155876 (7)c (6)d6 (8)c

e125959.tab.002e179-18049644

f125959.tab.002f203–20559014 (15)c (16)d4

g125959.tab.002g171-1725905 (5)c

h125959.tab.002h222–22449068 (10)c

i125959.tab.002i154-155495616 (18)c (17)d

j125959.tab.002j185–18758710 (12)c (11)d12 (12)c (13)d

k125959.tab.002k183–1855908 (10)c55

Gentamycin162019

DMSO

Isolated yields.
bIdentified by spectroscopic (FT-IR, 1H NMR, and 13C NMR) and elemental analyses.
cData of duplicated experiments.
d Data of triplicated experiments.