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Journal of Chemistry
Volume 2013 (2013), Article ID 147565, 5 pages
http://dx.doi.org/10.1155/2013/147565
Research Article

Synthesis and Antibacterial, Antimycobacterial Activity of 7-[4-{5-(2-Oxo-2-p-substituted-phenylethylthio)-1,3,4-thiadiazol-2yl}-3′-methylpiperazinyl] Quinolone Derivatives

1Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education & Research, Shirpur, Dhule District, Shirpvr 425405, India
2Department of Pharmaceutical Chemistry, Nashik Gramin Shikshan Prasarak Mandal's College of Pharmacy, Triambak Road, Anjaneri, Nashik 422213, India

Received 30 December 2011; Revised 6 May 2012; Accepted 16 May 2012

Academic Editor: Alessandro Volonterio

Copyright © 2013 Kapil M. Agrawal and Gokul S. Talele. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Currently we screened 9 newer synthesized fluoroquinolone derivatives 5(a–i) against two gram positive, two gram negative bacterial strains, and mycobacterium tuberculosis H37Rv. These analogues were confirmed by IR, 1H NMR, 13C NMR, and elemental analysis. Selected compounds were confirmed by mass spectral study. Compounds 5(b–d) showed comparable biological activities and other analogues of the series showed moderate-to-weak activity, as compared to the reference marketed drugs.