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Journal of Chemistry
Volume 2013, Article ID 151273, 10 pages
Research Article

- -Promoted Solvent-Free Synthesis of Benzoxazoles, Benzimidazoles, and Benzothiazole Derivatives

1Research and Development Division, RA Chem Pharma Limited, Prasanth Nagar, Hyderabad 500072, India
2Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, India

Received 10 June 2012; Revised 17 August 2012; Accepted 21 August 2012

Academic Editor: Antonio Romerosa

Copyright © 2013 K. Ravi Kumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


An efficient protocol has been developed for the preparation of a library of benzoxazole, benzimidazole, and benzothiazole derivatives from reactions of acyl chlorides with o-substituted aminoaromatics in the presence of catalytic amount of silica-supported sodium hydrogen sulphate under solvent-free conditions. Simple workup procedure, high yield, easy availability, reusability, and use of ecofriendly catalyst are some of the striking features of the present protocol.