Synthesis and Antimicrobial Evaluation of a New Series of N-1,3-Benzothiazol-2-ylbenzamides

Table 2

Antimicrobial activity results of benzothiazole derivatives 3a-l and 5a, b (MIC, μg/mL).

Microorganism (MIC, µg/mL)
	Gram positive^a		Gram negative^a	Fungi^b
	S.a. 29213	E.f. 29212	E.c. 25922	C.a. 10231	C.p. 22019	C.t. 750
3a	64	32	R	R	R	R
3b	R	32	R	R	R	R
3c	256	256	R	R	R	R
3d	R	R	256	R	R	R
3e	R	R	R	R	R	R
3f	R	32	R	R	R	R
3g	R	32	R	R	R	R
3h	R	32	R	R	R	R
3i	128	8	R	R	R	R
3j	256	128	R	R	R	R
3k	R	32	256	R	R	R
3l	R	R	R	R	R	R
5a	256	256	R	128	64	128
5b	128	128	256	64	128	128
OXA	0.25	16	R	—	—	—
NRF	0.5	4	0.03	—	—	—
FCN	—	—	—	2	2	4

aAntibacterial activity was estimated by using CLSI assay [36]. Abbreviations: S.a.: S. aureus; E.f.: E. faecalis; E.c.: E. coli; OXA: oxacillin; NRF: norfloxacin; R: resistant (>512 μg/mL).
^bAntifungal activity was estimated by using CLSI assay [37]. Abbreviations: C.a.: C. albicans; C.p.: C. parapsilosis; C.t.: C. tropicalis; C.k.: C. krusei; FCN: fluconazole; R: resistant (>512 μg/mL).