Genistein Derivatives Regioisomerically Substituted at 7-O- and 4′-O- Have Different Effect on the Cell Cycle

Table 2

Single-strand breaks (SSB) and double-strand breaks (DSB) detected with comet assays in HCT 116 cells.

Compound (µM)	Alkaline lysis—SSB	Neutral lysis—DSB
	Tail moment (%)
Control (0)	6.27±2.6	5.52±3.18
Gen-5′ (20)	3.9±1.61	7.17±4.82
Ram-2′ (3)	5.55±3.89	6.77±2.22
Ram-3′ (40)	5.39±0.14	6.43±4.29
Ram-5′ (20)	3.8±3.8	7.44±4.17
Etoposide (50)	10.8±1.82	12.63±1.31
Genistein [100]	31.67±3.71	0.45±0.2
Camptothecin (1)	50.94±5.12	1.07±0.1