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Journal of Chemistry
Volume 2013 (2013), Article ID 214617, 5 pages
Research Article

Superparamagnetic Iron Oxide as an Efficient Catalyst for the One-Pot, Solvent-Free Synthesis of 5,5-Disubstituted Hexahydropyrimidines and Their Spiro Analogues

1Department of Chemistry, Faculty of Sciences, Payame Noor University, Mashhad 91735-433, Iran
2Department of Chemistry, School of Sciences, Alzahra University, Vanak, Tehran, Iran

Received 3 September 2012; Revised 27 October 2012; Accepted 10 November 2012

Academic Editor: Saima Q. Memon

Copyright © 2013 Fatemeh Janati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Superparamagnetic Fe3O4 is shown to act as a very efficient catalyst for the one-pot, three-component synthesis of 5,5-disubstituted hexahydropyrimidines and their spiropiperidines. The catalyst is easily recovered by the use of an external magnet and reused in several reactions without any noticeable loss of activity. The products are obtained in short time and good purity upon separation of the catalyst and evaporation of the volatiles of the reaction mixture.