Molecular Modeling Studies of Piperidine Derivatives as New Acetylcholinesterase Inhibitors against Neurodegenerative Diseases

Table 1

Piperidine derivatives.

Compd.	IC50 (𝜇M)	R1	R2
1	7.2	NO2	H
2	0.3	Cl	H
3	0.84	F	H
4	1.3	H	H
5	3.89	CH(CH3)2	H
6	2.40	C(CH3)3	H
7	3.39	H	Cl
8	70.7	H	F
9	>100	NO2	H
10	>100	Cl	H
11	>100	F	H
12	>100	H	H
13	>100	H	Cl
14	>100	H	F