Molecular Modeling Studies of Piperidine Derivatives as New Acetylcholinesterase Inhibitors against Neurodegenerative Diseases

Table 4

Proposed structures of new potential inhibitors.

Compd.	R1	R2	R3	R4	pIC50Pred
A	H	Cl	H	Cl	5.12
B	OH	H	H	H	6.12
C	CHO	H	H	H	5.11
D	CH3	H	CH3	H	6.54
E	OCH3	H	OCH3	H	6.68
F	OCH3	OCH3	H	H	5.95
G	H	F	H	F	7.27
H	Cl	H	H	Cl	5.12
I	F	H	H	F	5.30
J	Cl	H	Cl	H	6.95
K	CH2CH3	H	CH2CH3	H	6.62
L	H	NO2	H	H	4.77
M	H	H	NO2		5.62
N	OH	H	CH3	H	6.92
O	H	OCH3	H	OCH3	6.34
P	NO2	H	CH3	H	6.07
Q	CHO	H	CHO	H	6.18