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Journal of Chemistry
Volume 2013, Article ID 296792, 6 pages
Research Article

A Convenient Synthesis of C-3-Aryloxymethyl Imidazo[1,2- ]Pyridine Derivatives

1School of Chemistry, University of Hyderabad, Andhra Pradesh, Hyderabad 500046, India
2Department of Chemistry, AG & SG Siddhartha Arts and Science College, Andhra Pradesh, Vuyyuru 521165, India

Received 16 June 2012; Accepted 26 July 2012

Academic Editor: Marco Radi

Copyright © 2013 Sridevi Kona et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Imidazo[1,2- ]pyridine-based tosylhydrazone was prepared and treated with K2CO3 in dioxane at 110°C to generate the corresponding carbene in situ. It was coupled with a variety of aryl alcohols in one pot to obtain a series of imidazo[1,2- ]pyridine derivatives possessing aryl ether moiety at C-3 position.