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Journal of Chemistry
Volume 2013 (2013), Article ID 325268, 5 pages
Research Article

Al(NO3)3 · 9H2O: An Efficient Catalyst for the One-Pot Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Both under Reflux or Solvent-Free Conditions

Department of Chemistry, Semnan University, P.O. Box 35195-363, Semnan, Iran

Received 23 January 2012; Accepted 30 May 2012

Academic Editor: Kotaro Satoh

Copyright © 2013 Eskandar Kolvari and Maryam Mirzaeeyan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Al(NO3)3 · 9H2O efficiently catalyzes the three-component Biginelli reaction between an aldehyde, a β-dicarbonyl compound, and urea or thiourea in refluxing ethanol and solvent-free (SF) conditions to afford the corresponding dihydropyrimidinones in high yields. The advantages of this method involve the easy procedure, the environmentally friendly process, and the low cost of the Lewis acid catalyst.