Research Article
An Alternative Route for Synthesis of Chiral 4-Substituted 1-Arenesulfonyl-2-imidazolidinones: Unusual Utility of (4S,5S)- and (4R,5R)-4,5-Dimethoxy-2-imidazolidinones and X-Ray Crystallography
Table 2
Stereoselective demethoxylation of sterically congested imidazolidinonesa 13 and 17 with organocupratesb.
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a(, )-enentiomer was used with -BuLi, while (, )-enentiomer was used with 1-adamantylMgBr. The reaction was performed by using Grignard reagent (4.0 eq), CuCN (4.4 eq), and BF3OEt2 (2.0 eq) in the presence of LiCl (8.8 eq) at 0°C, for 3 h, unless otherwise stated. |