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Journal of Chemistry
Volume 2013, Article ID 364036, 9 pages
Research Article

Comparative Studies on Conventional and Ultrasound-Assisted Synthesis of Novel Homoallylic Alcohol Derivatives Linked to Sulfonyl Dibenzene Moiety in Aqueous Media

1Department of Mathematics and Natural Sciences, Faculty of Science and Technology, University of Stavanger, 4036 Stavanger, Norway
2Department of Green Chemistry, National Research Centre, Dokki, Cairo 12622, Egypt
3Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Koam, Menoufia 32515, Egypt

Received 17 January 2012; Revised 23 May 2012; Accepted 31 May 2012

Academic Editor: Barbara Zajc

Copyright © 2013 Mohamed F. Mady et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Novel homoallylic alcohols incorporating sulfone moieties were synthesized by the treatment of different carbonyl compounds with allylic bromides in aqueous media via sonochemical Barbier-type reaction conditions. Sulfonation of α-bromoketones with sodium benzenesulfinate in presence of CuI/2,6-lutidine rapidly gave β-keto-sulfones in good yields. In general, ultrasound irradiation offered the advantages of high yields, short reaction times, and simplicity compared to the conventional methods. The structures of all the compounds were confirmed by analytical and spectral data.