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Journal of Chemistry
Volume 2013, Article ID 414185, 7 pages
http://dx.doi.org/10.1155/2013/414185
Research Article

Synthesis of Dextran/Methoxy Poly(ethylene glycol) Block Copolymer

1National Research and Development Center for Hepatobiliary Disease, Pusan National University Yangsan Hospital, Beomeo-ri, Mulgeum-eup, Yangsan, Gyeongnam 626-770, Republic of Korea
2Utah-Inha DDS & Advanced Therapeutics Research Center, Incheon 406-840, Republic of Korea

Received 26 April 2013; Revised 8 July 2013; Accepted 18 August 2013

Academic Editor: Mehdi Rajabi

Copyright © 2013 Young-Il Jeong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We synthesized a block copolymer composed of dextran and methoxy poly(ethylene glycol) (mPEG). To accomplish this, the end group of dextran was modified by reductive amination. The aminated dextran (Dextran-NH2) showed the intrinsic peaks of both dextran at 3~5.5 ppm and hexamethylene diamine at 1~2.6 ppm at 1H nuclear magnetic resonance (NMR) spectrum. The amino end group of dextran was conjugated with mPEG to make the block copolymer consisting of dextran/mPEG (abbreviated as DexPEG). The synthesized aminated dextran and DexPEG were characterized using 1H NMR and gel permeation chromatography (GPC). The molecular weight and conjugation yield were estimated by comparing the intensity ratio of the proton peaks of the glucose molecule (4.9 ppm and 3.3~4.0 ppm) to that of the ethylene group of mPEG (3.7 ppm). Abundant hydroxyl group in the dextran chain can be used as a source of bioactive agent conjugation.