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Journal of Chemistry
Volume 2013, Article ID 427158, 10 pages
Research Article

The Reaction of Cyclopentanone with Cyanomethylene Reagents: Novel Synthesis of Pyrazole, Thiophene, and Pyridazine Derivatives

National Organization for Drug Control & Research, P.O. Box 29, Cairo, Egypt

Received 28 May 2013; Revised 1 September 2013; Accepted 6 September 2013

Academic Editor: Alexander Kornienko

Copyright © 2013 Wagnat W. Wardakhan and Eman M. Samir. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The reaction of cyclopentanone with either malononitrile or ethyl cyanoacetate gave the corresponding condensated products. The latter underwent some heterocyclic reactions to give new pyrazole, thiophene, and pyridazine derivatives. The antitumor evaluation of the newly synthesized products against the three cancer cells, namely, breast adenocarcinoma (MCF-7), nonsmall cell lung cancer (NCI-H460), and CNS cancer (SF-268) showed that some of them have high inhibitory effect towards three cell lines which is higher than the standard.