Journal of Chemistry / 2013 / Article / Tab 3

Research Article

The Reaction of Cyclopentanone with Cyanomethylene Reagents: Novel Synthesis of Pyrazole, Thiophene, and Pyridazine Derivatives

Table 3

Effect of compounds 3a,b15a,b on the growth of three human tumor cell lines.

CompoundGI50 ( mol L−1)
MCF-7 NCI-H460 SF-268

3a
3b
5a
5b
5c
5d
7a
7b
7c
7d
9a
9b
11a
11b
11c
11d
12a
12b
13a
13b
14a
14b
15a
15b
16a
16b
Doxorubicin

Results are given in concentrations that were able to cause 50% of cell growth inhibition (GI50) after a continuous exposure of 48 h and show means ± SEM of three-independent experiments performed in duplicate.

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