Synthesis and Evaluation of Novel Fluorinated 2-Styrylchromones as Antibacterial Agents
Figure 1
The preparation of 2-styrylchromones 5a–j from their corresponding acetophenones and benzaldehydes (i) malonic acid, piperidine, pyridine, 80–90°C, 4-5 h, (ii) pyridine, POCl3, rt. 4-5 h, (iii) DMSO, KOH, rt. 2 h, and (iv) DMSO, PTSA, 90–95°C, 2-3 h.
