Synthesis and Biological Evaluation of New N,N′-Bis(1-substituted-ethylidene)-ethane1,2-diamine and Their Acetyl and Trifluoroacetyl Derivatives as Cytotoxic and Antimicrobial Agents

Figure 1

X-ray crystal structures of 2e, 2f, 3c, and 5a.

(a) N,N′-Bis[1-(thiophen-2-yl)ethylidene]ethane-1,2-diamine (2e)

(b) N,N′-Bis[(E)-1-(thiophen-3-yl)ethylidene]ethane-1,2-diamine (2f)

(c) 1,1,1-Trifluoro-4-(thiophen-2-yl)-4-[(2-{[4,4,4-trifluoro-3-oxo-1-(thiophen-2-yl)but-1-en-1-yl]amino}ethyl)amino]but-3-en-2-one (3c)

(d) 2-Hydroxy-2-trifluoro-methyl-3,4-dihydro-2H-1-benzopyran-4-one (5a)