Synthesis and Biological Evaluation of New N,N′-Bis(1-substituted-ethylidene)-ethane1,2-diamine and Their Acetyl and Trifluoroacetyl Derivatives as Cytotoxic and Antimicrobial Agents

Scheme 1

Synthesis of Schiff bases of 1,2-diamine. i: appropriate ketone (20 mmol) 1,2-diaminoethane (10 mmol, 0.6 g), dry benzene (50 mL), and reflux using Dean-Stark trap ~2 h; ii: N,N′-bis(1-substituted-ethylidene)-ethane-1,2-diamine (10 mmol), THF (30 mL), (CF₃CO)O (25 mmol), and reflux 2 h; iii: N,N′-bis(1-substituted-ethylidene)ethane-1,2-diamine (10 mmol), THF (30 mL), (CF₃CO)O (25 mmol), and reflux 2 h.