Journal of Chemistry

Research Article

Synthesis and Biological Evaluation of New N,N′-Bis(1-substituted-ethylidene)-ethane1,2-diamine and Their Acetyl and Trifluoroacetyl Derivatives as Cytotoxic and Antimicrobial Agents

Table 2

¹H and ¹³C NMR spectral data (/ppm)^a of compound series 2.


Compd.	R	¹H NMR			¹³C NMR
Compd.	R	CH₃ (s)	CH₂ (s)^b	Ar-H (m)	CH₃	CH₂	C=N	Ar-C

2a	C₆H₅	2.32	3.94	7.62–7.29 (10H)	14.6	48.2	164.8	128.5, 129.1, 130.6, 137.3
2b	4-BrC₆H₄	2.29	3.91	7.46–7.51 (8H)	14.5	48.4	164.6	125.3, 131.3, 132.0, 136.5
2c	2-OHC₆H₄	2.36	3.82	6.77–7.51 (8H)^c	14.9	48.1	164.5	115.9, 121.2, 124.6, 130.6, 132.3, 157.8
2d	2-CH₃OC₆H	2.38, 3.73^d	3.79	6.80–7.51 (8H)	14.8, 56.0^d	47.9	164.2	114.2, 120.9, 122.8, 130.1, 131.8, 162.5
2e	2-Thienyl	2.30	3.50	6.98–7.32 (6H)	15.3	48.3	164.7	126.4, 127.6
2f	3-Thienyl	2.32	3.48	7.02–7.28 (6H)	15.2	48.2	164.8	126.8, 127.9, 130.2
2g	2-Furyl	2.39	3.39	6.51–7.43 (6H)	15.4	45.3	164.6	110.4, 143.6
2h	2-Pyridyl	2.19	3.19	7.63–8.83 (8H)	14.6	48.4	164.4	124.3, 125.7, 135.1, 149.8, 158.6
2i	4-CH₃C₆H₄	2.33, 2.41	3.89	7.09–7.51 (8H)	14.6, 20.7	48.3	164.6	128.9, 129.3, 134.3, 140.0
2j	4-CH₃OC₆H₄	2.30, 3.75^d	3.92	6.81–7.54 (8H)	14.7, 56.0^d	48.0	164.6	114.4, 129.6, 130.3, 163.9
2k	3,4-(CH₃O)₂C₆H₄	2.36, 3.73^d 3.80^d	3.91	6.69–7.02 (6H)	14.4, 56.3^d, 56.4^d	48.2	164.8	115.4, 115.8, 122.6, 130.8, 147.8, 150.1

Solution in CDCl₃; ^b(2CH₂, 4H); ^c12.3 (broad singlet, OH); ^dOCH₃.