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Journal of Chemistry
Volume 2013 (2013), Article ID 495982, 6 pages
Research Article

Synthesis of 1,4-Dihydropyridines Bearing a Carbamate Moiety on the 4-Position

Department of Organic Chemistry, Faculty of Chemistry, Bu-Ali Sina University, Hamedan 6517838683, Iran

Received 20 May 2013; Accepted 8 July 2013

Academic Editor: Augusto C. Tome

Copyright © 2013 Davood Habibi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A good range of 1,4-dihydropyridines bearing a carbamate moiety on the 4-position were synthesized from the primary reaction of different hydroxyaldehydes with phenyl isocyanates and the subsequent reaction of the obtained carbamates with methyl acetoacetate in the presence of ammonium fluoride. When phenyl isothiocyanate was used in place of phenyl isocyanate in the same condition, the reaction did not take place.