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Journal of Chemistry
Volume 2013, Article ID 542973, 4 pages
Research Article

Green Synthesis and In Vitro Biological Evaluation of Heteroaryl Chalcones and Pyrazolines of Medicinal Interest

Department of Chemistry, Government Vidarbha Institute of Science & Humanities, Amravati 444 604, India

Received 28 May 2013; Revised 11 September 2013; Accepted 19 September 2013

Academic Editor: Naoki Haraguchi

Copyright © 2013 Vishal Banewar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pyrazolines are well known and important nitrogen containing 5-membered heterocyclic compounds. In the present investigation, a series of various heteroaryl chalcones and pyrazolines were synthesized by condensing formylquinolines with diverse ketones. The newly synthesized 2-pyrazolines were characterized on the basis of elemental analysis and spectroscopic data. All of the newly synthesized target compounds were selected by the NCI for in vitro biological evaluation. These active compounds exhibited broad spectrum of various biological activities. Most of the compounds showed potent activity.