Table of Contents Author Guidelines Submit a Manuscript
Journal of Chemistry
Volume 2013, Article ID 542973, 4 pages
Research Article

Green Synthesis and In Vitro Biological Evaluation of Heteroaryl Chalcones and Pyrazolines of Medicinal Interest

Department of Chemistry, Government Vidarbha Institute of Science & Humanities, Amravati 444 604, India

Received 28 May 2013; Revised 11 September 2013; Accepted 19 September 2013

Academic Editor: Naoki Haraguchi

Copyright © 2013 Vishal Banewar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. K. Dodiya, Studies on heterocyclic compounds of medicinal interest [Ph.D. thesis], Saurashtra University, Gujrat, India, 2010.
  2. A. Ganesh, “Biological activities of some Pyrazoline derivatives,” International Journal of Pharma and Bio Sciences, vol. l4, no. 2, pp. 727–733, 2013. View at Google Scholar
  3. O. Ruhoǧlu, Z. Özdemir, Ü. Çaliş, B. Gümüşel, and A. A. Bilgin, “Synthesis of and pharmacological studies on the antidepressant and anticonvulsant activities of some 1,3,5-trisubstituted pyrazolines,” Arzneimittel-Forschung/Drug Research, vol. 55, no. 8, pp. 431–436, 2005. View at Google Scholar · View at Scopus
  4. S. A. Thakkar, Studies on bioactive heterocycles and other moieties [Ph.D. thesis], Saurashtra University, Gujrat, India, 2010.
  5. A. Handan, A. Oznur, K. Ayse, B. Seher, and O. Gulten, “Synthesis, characterization and evaluation of antimicrobial activity of Mannich bases of some 2-[(4-carbethoxymethylthiazol-2-yl)imino]-4-thiazolidinones,” Indian Journal of Chemistry, vol. 44B, p. 585, 2005. View at Google Scholar
  6. J. T. Desai, C. K. Desai, and K. R. Desai, “A convenient, rapid and eco-friendly synthesis of isoxazoline heterocyclic moiety containing bridge at 2-amine as potential pharmacological agent,” Journal of the Iranian Chemical Society, vol. 5, no. 1, pp. 67–73, 2008. View at Google Scholar · View at Scopus
  7. V. Klimešová, M. Otčenášek, and K. Waisser, “Potential antifungal agents. Synthesis and activity of 2-alkylthiopyridine-4-carbothioamides,” European Journal of Medicinal Chemistry, vol. 31, no. 5, pp. 389–395, 1996. View at Publisher · View at Google Scholar · View at Scopus
  8. E. Suloeva, M. Yure, E. Gudriniece, M. Petrova, and A. Gutcaits, “Synthesis of 2,3-dihydroimidazo-[1,2-a]pyridines from 1,3-diketones,” Chemistry of Heterocyclic Compounds, vol. 37, no. 7, pp. 872–875, 2001. View at Publisher · View at Google Scholar · View at Scopus
  9. J. M. Quintela, C. Peinador, L. Botana, M. Estévez, and R. Riguera, “Synthesis and antihistaminic activity of 2-guanadino-3-cyanopyridines and pyrido[2,3-d]-pyrimidines,” Bioorganic and Medicinal Chemistry, vol. 5, no. 8, pp. 1543–1553, 1997. View at Publisher · View at Google Scholar · View at Scopus
  10. B. Abarca, I. Alkorta, R. Ballesteros et al., “3-(2-Pyridyl)-[1,2,3]triazolo[1,5-a]pyridines. An experimental and theoretical (DFT) study of the ring-chain isomerization,” Organic and Biomolecular Chemistry, vol. 3, no. 21, pp. 3905–3910, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. B. Abarca, R. Ballesteros, and M. Chadlaoui, “Synthesis of novel polypyridylcarbonylpyridines from triazolopyridines. Building blocks in supramolecular chemistry,” Arkivoc, vol. 2008, no. 7, pp. 73–83, 2008. View at Google Scholar · View at Scopus
  12. B. Abarca, R. Ballesteros, M. Elmasnaouy, P. D'Ocón, M. D. Ivorra, and M. Valiente, “Evaluation and synthesis of 7-arylhydroxymethyltriazolopyridines as potential cardiovascular agents,” ARKIVOC, vol. 2002, no. 10, pp. 9–13, 2002. View at Google Scholar · View at Scopus
  13. Y. S. Sanghvi, S. B. Larson, R. C. Willis, R. K. Robins, and G. R. Revankar, “Synthesis and biological evaluation of certain C-4 substituted pyrazolo[3,4-b]pyridine nucleosides,” Journal of Medicinal Chemistry, vol. 32, no. 5, pp. 945–951, 1989. View at Google Scholar · View at Scopus
  14. M. Paller and K. Ponzio, Chemical Abstracts, vol. 99, p. 158406r, 1983.
  15. M. Kidwai, P. Priya, and S. Rastogi, “Reaction of coumarin derivatives with nucleophiles in aqueous medium,” Zeitschrift für Naturforschung Section B, vol. 63, no. 1, pp. 71–76, 2008. View at Google Scholar · View at Scopus
  16. L. Prakash, R. Sharma, S. Shukla, and G. R. D. Pharmazie, Pharmazie, vol. 48, p. 221, 1993.
  17. J. P. Raval and K. R. Desai, “Synthesis and antimicrobial activity of new triazolopyridinyl phenothiazines,” ARKIVOC, vol. 2005, no. 13, pp. 21–28, 2005. View at Google Scholar · View at Scopus
  18. A. Heichachiro, K. Shinozaki, S. Niwa et al., Chemical Abstracts, vol. 110, p. 23891v, 1989.
  19. K. Bajaj, V. K. Srivastava, and A. Kumar, “Synthesis and psychotropic evaluation of some new N-substitutedbenzothia/oxazepinylphenothiazines,” Indian Journal of Chemistry Section B, vol. 43, no. 1, pp. 157–161, 2004. View at Google Scholar · View at Scopus
  20. M. N. Narule, “A facile route to the synthesis of 8-[2-(3, 5-dimethyl-4-ethoxy carbonyl pyrrolyl) hydrazine] substituted phenothiazines and their biological activity,” Journal of Chemical, Biological and Physical Sciences, vol. 2, no. 4, pp. 1681–1687, 2012. View at Google Scholar
  21. M. Idries and A. L. Abeed-Mashkor, “Synthesis of new [10h-substitutedphenoxazine-3-Yl)-6-pyrimidin-2-phenylthiol/Ol/amine/thiol] pyrroles,” Thi-Qar Medical Journal, vol. 4, no. 4, pp. 120–126, 2010. View at Google Scholar
  22. R. Dahlbom and T. Ekstrand, Archive of International Pharmacodynamics, vol. 159, p. 70, 1996.
  23. C. S. Weil, “On the construction of tables for moving average interpolation,” Biometrics, vol. 8, p. 249, 1952. View at Google Scholar
  24. B. Harpen and M. Nidwai, “Synthesis characterization of Phenothiazinly derivatives,” The Journal of the American Medical Association, vol. 129, pp. 1219–1222, 1945. View at Google Scholar
  25. M. Narule, J. M. B. Santhakumari, and A. Shanware, “Synthesis of 2-[4-(10H-substituted phenothiazine-3-yl)-6-pyrimidin-2- phenylthiol/ol/amine/thiol] pyrroles,” E-Journal of Chemistry, vol. 4, no. 1, pp. 53–59, 2007. View at Google Scholar · View at Scopus
  26. J. D. Genzer, M. N. Lewis, F. H. McMillan, and J. A. King, “Synthesis and anti-microbial activity of 2-[4-(10-p-chlorobenzyl)phenothiazinyl]-3-substituted aryl-1-ones,” Journal of the American Chemical Society, vol. 75, p. 2206, 1953. View at Google Scholar
  27. L. Dushay, Revue Canadienne de Biologie, vol. 20, p. 321, 1961.
  28. J. R. Douglass, N. F. Baker, and M. W. Longwest, “Synthesis and biological activity of N-phenothiazine,” American Journal of Veterinary Research, vol. 17, p. 318, 1956. View at Google Scholar
  29. O. Meth-Cohn, B. Narine, and B. Tarnowski, “A versatile new synthesis of quinolines and related fused pyridines. Part 5. The synthesis of 2-chloroquinoline-3-carbaldehydes,” Journal of the Chemical Society, Perkin Transactions 1, pp. 1520–1530, 1981. View at Publisher · View at Google Scholar · View at Scopus
  30. F. Herencia, M. L. Ferrándiz, A. Ubeda et al., “Synthesis and anti-inflammatory activity of chalcone derivatives,” Bioorganic and Medicinal Chemistry Letters, vol. 8, no. 10, pp. 1169–1174, 1998. View at Publisher · View at Google Scholar · View at Scopus
  31. T. Narender, K. Venkateswarlu, B. V. Nayak, and S. Sarkar, “A new chemical access for 3-acetyl-4-hydroxychalcones using borontrifluoride-etherate via a regioselective Claisen-Schmidt condensation and its application in the synthesis of chalcone hybrids,” Tetrahedron Letters, vol. 52, no. 44, pp. 5794–5798, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. R. Li, G. L. Kenyon, F. E. Cohen et al., “In vitro antimalarial activity of chalcones and their derivatives,” Journal of Medicinal Chemistry, vol. 38, no. 26, pp. 5031–5037, 1995. View at Google Scholar · View at Scopus