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Journal of Chemistry
Volume 2013 (2013), Article ID 543219, 4 pages
Research Article

Molecular Iodine: A Powerful Catalyst for the Knoevenagel Condensation of Isatins with Malononitrile

1College of Chemistry and Chemical Engineering, Xinxiang University, Henan, Xinxiang 453003, China
2The Third Affiliated Hospital, Xinxiang Medical University, Henan, Xinxiang 45300, China

Received 21 June 2012; Accepted 11 August 2012

Academic Editor: Xinyong Liu

Copyright © 2013 Xiao Juan Yang and Yong Sen Zhang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Molecular iodine has been used as an efficient catalyst for an improved and rapid condensation of isatins with malononitrile in excellent yields. The significant features of the iodine-catalyzed Knoevenagel condensation are operational simplicity, inexpensive reagents, high yield of products, and the use of nontoxic reagents.