Journal of Chemistry / 2013 / Article / Tab 3

Research Article

Molecular Iodine: A Powerful Catalyst for the Knoevenagel Condensation of Isatins with Malononitrile

Table 3

Comparison of the effect of catalysts in synthesis of 3a.

EntryReagent and conditionsTime (min)Yield (%)bReference

1Piperidine acetate, CH3CN, reflux12085[5]
2DBU, EtOH, reflux1588[6]
3Piperidine, EtOH, reflux1584[6]
4Al2O3, acetone, MW578[7]
5I2, EtOH, 60°C597The study

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