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Journal of Chemistry
Volume 2013, Article ID 568907, 4 pages
Research Article

Synthesis of Novel S-Glucosides Containing 5-Methylisoxazole Substituted 1,2,4-Triazole

Department of Chemistry, Xinxiang Medical University, Henan, Xinxiang 453003, China

Received 1 April 2012; Accepted 19 May 2012

Academic Editor: Lorenzo Cerretani

Copyright © 2013 Shujun Chao and Yingling Wang. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Nine new S-β-D-glucosides containing 4-aryl-5-(5-methylisoxazol-3-yl)-1,2,4-triazol-3-thiols have been synthesized by the direct glycosylation of 4-aryl-5-(5-methylisoxazol-3-yl)-1,2,4-triazol-3-thiols with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide in ethanol in the presence of potassium hydroxide followed by deacetylation using dry ammonia in dry methanol. All the compounds synthesized have been characterized by their elemental analyses and spectral data.