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Journal of Chemistry
Volume 2013, Article ID 576370, 9 pages
Research Article

Modified Chitosan-Clay Nanocomposite as a Drug Delivery System Intercalation and In Vitro Release of Ibuprofen

1Biology Department, King Khalid University, Saudi Arabia
2Department of Chemistry, Polymer Research Group, Faculty of Science, Tanta University, Egypt

Received 3 April 2013; Accepted 6 September 2013

Academic Editor: Ali Nokhodchi

Copyright © 2013 Rehab Abdeen and Nehal Salahuddin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present paper focused on the intercalation of ibuprofen into sodium montmorillonite, chitosan, and chitosan montmorillonite nanocomposites as a sustained release drug carrier. The compounds were characterized by X-ray diffraction (XRD), infrared spectroscopy (IR), thermogravimetric analysis (TGA), and transmission electron microscopy (TEM). The basal spacing of montmorillonite increased from 9.6 Å to 19.6 Å indicating the intercalation of modified chitosan and ibuprofen between lamellar layers. UV spectroscopy was employed to monitor the in vitro drug release processes in both pH 5.4 and 7.8 solutions. The results revealed that ibuprofen was released from MMT, CS, and Mod-CS/MMT steadily and was pH dependent.