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Journal of Chemistry
Volume 2013 (2013), Article ID 578438, 5 pages
http://dx.doi.org/10.1155/2013/578438
Research Article

Microwave-Assisted Synthesis of Some Quinoxaline-Incorporated Schiff Bases and Their Biological Evaluation

Department of Pharmaceutical Chemistry, G. Pulla Reddy College of Pharmacy, Mehdipatnam, Hyderabad 500 028, India

Received 4 December 2011; Accepted 9 May 2012

Academic Editor: Aleš Imramovsky

Copyright © 2013 L. Achutha et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Quinoxaline-incorporated Schiff bases (4a–j) were synthesized by the condensation of 2-[(3-methylquinoxalin-2-yl)oxy]acetohydrazide (3) with indole-3-carbaldehyde, furfuraldehyde, 5-(4-nitrophenyl)-2-furfuraldehyde, and substituted benzaldehydes under conventional and microwave irradiation methods. The microwave method was found to be remarkably successful with higher yields, less reaction time, and environmentally friendly compared to conventional heating method. The chemical structures of the synthesized compounds have been confirmed by analytical and spectral data. All the compounds have been evaluated for antitubercular and anti-inflammatory activities.