Validation of Quetiapine Fumarate in Pharmaceutical Dosage by Reverse-Phase HPLC with Internal Standard Method

Table 5

Intraday and interday precision and accuracy of HPLC assay of quetiapine fumarate.

Nominal concentration
	5.12×10^−3 g/Lt	15.06×10^−3 g/Lt	40.16×10^−3 g/Lt
Day 1
Mean (𝑛=3)	183638	502614	1297619
S.D	948.01	10442.68	1514.80
R.S.D	0.52	2.07	0.12
Recovery (%)	100.4907	100.11	99.49
Day 2
Mean (𝑛=3)	227511	523982	1310744
S.D	379.36	3262.83	21904
R.S.D	0.17	0.62	1.67
Recovery (%)	100.64	101.00	99.52
Day 3
Mean (𝑛=3)	199599	516802	1293679
S.D	1216.50	4041.45	1760.91
R.S.D	0.61	0.78	0.14
Recovery (%)	99.36	101.50	99.69

Each mean value is a result of triplicate analysis (𝑛=3).