A Simple and Green Protocol for 2H-Indazolo[2,1-b]phthalazine-triones Using Grinding Method

Table 2

Synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives under grinding.

Entry	Ar	R	𝑡 (min)	Product	Yield (%)^a
1	C6H5	CH3	2	a	91
2	4-CH3C6H4	CH3	2	b	90
3	4-CH3OC6H4	CH3	5	c	88
4	4-FC6H4	CH3	2	d	87
5	4-ClC6H4	CH3	2	e	86
6	2-ClC6H4	CH3	2	f	83
7	4-BrC6H4	CH3	2	g	85
8	4-NO2C6H4	CH3	2	h	92
9	4-OHC6H4	H	5	i	86
10	4-(CH3)2NC6H4	H	5	j	84
11	2-Naphthyl	H	2	k	89
12	4-CH3C6H4	H	2	l	90

aIsolated yields.