Synthesis, Characterization, and Biological Activity of Novel Schiff and Mannich Bases of 4-Amino-3-(N-phthalimidomethyl)-1,2,4-triazole-5-thione

Table 1

In vitro antimicrobial screening of compounds (mm) conc. 100 µg/mL.

Compound no.	Microorganisms and inhibition zone (mm)
	Escherichia coli	Pseudomonas aeruginosa	Enterobacter cloacae	Klebsiella pneumoniae	Staphylococcus aureus	Candida albicans
3	7.00	8.00	9.68	9.40	7.00	9.95
4a	10.25	8.60	11.65	12.35	9.10	10.00
4b	8.52	9.65	14.42	11.20	8.10	11.75
4c	6.75	8.10	8.00	10.20	7.25	11.25
4d	7.38	9.30	9.60	9.83	8.00	10.76
4e	7.30	8.37	12.20	9.42	7.67	9.72
4f	8.21	8.43	9.33	10.70	9.42	10.45
4g	7.22	10.90	7.30	7.10	7.10	12.30
4h	6.55	6.95	7.30	7.44	8.0	7.82
4i	7.1	8.11	8.63	7.50	7.43	10.28
5a	13.2	13.20	—	11.10	12.60	14.30
5b	13.0	14.10	—	11.70	11.60	15.10
5c	7.00	10.00	9.00	11.00	11.00	13.20
5d	11.60	13.80	—	12.40	14.00	12.40
5e	12.50	14.80	—	12.00	14.10	13.70
5f	11.30	14.10	—	11.10	12.20	13.20
5g	—	—	—	—	10.00	12.20
5h	14.70	11.40	—	13.20	14.20	14.60
Levofloxacin	16.50	13.85	14.80	13.95	18.32	—
Fluconazole	—	—	—	—	—	17.25
Amikacin	17.70	12.75	16.30	14.20	19.20	—