Synthesis and Evaluation of Some New Thiazolidin-4-One Derivatives as Potential Antimicrobial Agents

Table 3

Antimicrobial and antifungal activity of compounds (7a-l).

Compound	R	Antibacterial^a				Antifungal^a
		S.a.	P.a.	E.c.	S.t.	A.n.	C.a.
7a	H–	18	26	20	22	19	26
7b	2-OH–	16	11	15	14	14	10
7c	4-Cl–	12	22	10	20	24	24
7d	3-NO2–	10	08	11	09	13	12
7e	2-NO2–	09	07	10	09	09	07
7f	4-OH–	14	25	17	22	18	23
7g	4-(CH3)2N–	18	23	21	18	19	16
7h	3,4,5-(OCH3)3–	10	12	12	14	17	15
7i	4-OCH3–	08	12	10	11	09	13
7j	4-Br–	11	24	12	19	22	28
7k	4-CH3–	20	27	21	25	20	25
7l	4-F–	13	15	13	19	12	16
Penicillin	—	22	30	28	26	—	—
Griseofulvin	—	—	—	—	—	28	34

^aZone of inhibition is measured in mm.
S.a.: Staphylococcus aureus, E.c.: Escherichia coli, P.a.: Pseudomonas aeruginosa, S.t.: Salmonella typhi, A.n.: Aspergillus niger, C.a.: Candida albicans.