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Journal of Chemistry
Volume 2013 (2013), Article ID 679857, 5 pages
http://dx.doi.org/10.1155/2013/679857
Research Article

Simultaneous Spectrophotometric Estimation of Artesunate and Mefloquine

1Department of Pharmaceutical Chemistry, School of Pharmacy, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded 431606, India
2Department of Pharmaceutical Sciences, R. T. M. Nagpur University, Nagpur 440010, India

Received 21 June 2012; Accepted 27 September 2012

Academic Editor: Benoit Braïda

Copyright © 2013 T. M. Kalyankar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A simple, rapid, precise, and accurate UV-visible spectrophotometric method has been developed for the simultaneous determination of Artesunate in combination with Mefloquine. For developing the method, methanol was used as a solvent. Artesunate and Mefloquine showed   at  240 nm and 222 nm, respectively. The proposed method was validated as per ICH guideline. The linearity range of Artesunate and Mefloquine were 10–60 and 20–120 μg/mL, respectively. 99.91  ±  0.2740 and 99.56 ± 0.2067  these value represent the percent recovery of Artesunate and Mefloquine respectively The correlation coefficients of Artesunate and Mefloquine were 0.999, and 0.999, respectively. The relative standard deviation for six replicates was always less than 2%. The statistical analysis proves that the method is suitable for the analysis of Artesunate and Mefloquine as the bulk drugs and in pharmaceutical formulation without any interference from the excipients.