Ultrasonication-Induced Synthesis and Antimicrobial Evaluation of Some Multifluorinated Pyrazolone Derivatives

Table 3

Antibacterial and antifungal data of newly synthesized pyrazole-pyrazolone (4a–j) and chromone-pyrazolone (5a–i) indicated by MIC values (𝜇g/mL).

Compound	Minimum inhibitory concentration (MIC, 𝜇g/mL)
	Gram-positive bacteria		Gram-negative bacteria		Fungi
	S. aureus	S. pyogenes	E. coli	P. aeruginosa	C. albicans	A. niger	A. clavatus
4a	250	200	200	100	>1000	>1000	>1000
4b	125	100	62.5	100	500	1000	1000
4c	200	250	100	125	1000	1000	1000
4d	100	100	62.5	200	1000	>1000	>1000
4e	125	62.5	200	250	>1000	>1000	>1000
4f	200	250	250	250	1000	500	500
4g	250	200	100	200	>1000	250	500
4h	500	250	250	125	>1000	500	500
4i	500	500	200	200	500	>1000	>1000
4j	250	500	125	250	500	1000	1000
5a	200	250	250	125	500	1000	1000
5b	100	62.5	200	100	1000	>1000	>1000
5c	125	100	250	200	1000	>1000	>1000
5d	200	200	250	200	>1000	500	500
5e	100	100	500	200	250	1000	>1000
5f	62.5	200	500	500	250	>1000	>1000
5g	100	250	200	200	500	>1000	>1000
5h	250	200	100	250	1000	>1000	>1000
5i	250	200	125	62.5	1000	500	1000
Ampicillin	250	100	100	100	—	—	—
Griseofulvin	—	—	—	—	500	100	100