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Journal of Chemistry
Volume 2013, Article ID 765768, 6 pages
Research Article

Design, Synthesis, and In Vitro Antioxidant Activity of 1,3,5-Trisubstituted-2-pyrazolines Derivatives

1Manipal College of Pharmaceutical Sciences, Manipal, India
2Novarstis Healthcare Private Limited, Hyderabad, Andhra Pradesh, India
3Department of Pharmaceutical Sciences, Sam Higginbottom Institute of Agriculture, Technology and Sciences Deemed to be University, Allahabad, Uttar Pradesh 211007, India

Received 31 May 2013; Revised 29 August 2013; Accepted 2 September 2013

Academic Editor: Mire Zloh

Copyright © 2013 P. C. Jagadish et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Mannich base of pyrazolines 3(a–e) under both conventional and microwave irradiation was synthesized. All the synthesised compounds were purified by recrystallisation, characterized on the basis of UV, IR, and NMR spectroscopy, and further supported by mass spectroscopy. The result obtained confirms superiority of microwave irradiation method over classical heating one. The molecular properties and Lipinski rule of five for compounds 3(a–e) were determined by Molinspiration. The synthesized compounds were subsequently evaluated for the antioxidant activity. All the compounds were found in compliance with Lipinski “Rule of Five”, and compound 3e having p-hydroxyl substitution showed best antioxidant activity as compared to ascorbic acid and rutin.