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Journal of Chemistry
Volume 2013 (2013), Article ID 785753, 8 pages
http://dx.doi.org/10.1155/2013/785753
Research Article

Rapid and Economic Access to Some NSAIDS-Based Bioactive Heterocycles

1Department of Pharmaceutical Chemistry, C.U. Shah College of Pharmacy, S.N.D.T. Women's University, Santacruz (West), Maharashtra, Mumbai 400 049, India
2Department of Pharmaceutical Chemistry, V.E.S. College of Pharmacy, Chembur, Mumbai 400074, India
3Department of Pharmaceutical Chemistry, Bharati Vidyapeeth’s College of Pharmacy, Sector 8, C.B.D. Belapur, Maharashtra, Navi Mumbai 400614, India

Received 17 June 2012; Revised 4 August 2012; Accepted 22 August 2012

Academic Editor: Bartolo Gabriele

Copyright © 2013 A. V. Chavan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The use of microwave energy for the synthesis is considered as one of the alternate strategies. The present work includes the synthesis of some newer 2,5-disubstituted-1,3,4-oxadiazole analogues using both conventional and alternate rapid methods.The conventional method involves the synthesis of the target molecules by using cyclodehydrating agent like POCl3, while the other method consists of using some catalytic reagents like PbO2. Also, the short reaction time provided by microwave synthesis makes it ideal for the reaction. Hence, this project describes an efficient and operationally simple method for the microwave-assisted synthesis of some bioactive heterocycles based on NSAIDs.