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Journal of Chemistry
Volume 2013 (2013), Article ID 825290, 8 pages
http://dx.doi.org/10.1155/2013/825290
Research Article

Antihyperlipidemic Potential of Polyphenol and Glycoside Rich Nerium oleander Flower against Triton WR-1339-Induced Hyperlipidemia in Experimental Sprague Dawley Rats

1Department of Biotechnology, Mother Terasa Women’s University, Kodaikanal 624102, India
2Department of Biotechnology, School of Life Sciences, Pondicherry University, Puducherry 605014, India

Received 11 February 2012; Revised 2 May 2012; Accepted 31 May 2012

Academic Editor: Devanand Luthria

Copyright © 2012 V. Gayathri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. S. Goenka, D. Prabhakaran, V. S. Ajay, and K. S. Reddy, “Preventing cardiovascular disease in India-translating evidence to action,” Current Science, vol. 97, no. 3, pp. 367–377, 2009. View at Google Scholar · View at Scopus
  2. J. M. Torpy, A. E. Burke, and R. M. Glass, “Neurofibromatosis,” Journal of the American Medical Association, vol. 302, no. 19, p. 2170, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. H. Hicham, S. C. Hana, H. B. Nourel, A. Mohammed, and A Souliman, “Hypolipemic activity of polyphenol-rich extracts from Ocimum basilicum in Triton WR-1339-induced hyperlipidemic mice,” Food Chemistry, vol. 108, no. 1, pp. 205–212, 2008. View at Publisher · View at Google Scholar · View at Scopus
  4. A. M. Diego, I. NebojsaIlic, P. Alexander, and R. Ilya, “Effects of Arachis hypogaea nutshell extract on lipid metabolic enzymes and obesity parameters,” Life Sciences, vol. 78, no. 24, pp. 2797–2803, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. J. C. La Rosa, D. Hunninghake, D. Bush et al., “The cholesterol facts. A summary of the evidence relating dietary fats, serum cholesterol, and coronary heart disease. A joint statement by the American Heart Association and the National Heart, Lung, and Blood Institute,” Circulation, vol. 81, no. 5, pp. 1721–1733, 1990. View at Google Scholar · View at Scopus
  6. A. K. Khanna, F. Rizvi, and R. Chander, “Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats,” Journal of Ethnopharmacology, vol. 82, no. 1, pp. 19–22, 2002. View at Publisher · View at Google Scholar · View at Scopus
  7. I. Prassas and E. P. Diamandis, “Novel therapeutic applications of cardiac glycosides,” Nature Reviews Drug Discovery, vol. 7, no. 11, pp. 926–935, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Chen and X. Li, “Hypolipidemic effect of flavonoids from mulberry leaves in triton WR-1339 induced hyperlipidemic mice,” Asia Pacific Journal of Clinical Nutrition, vol. 16, supplement 1, pp. 290–294, 2007. View at Google Scholar
  9. M. B. Engler and M. M. Engler, “The vasculoprotective effects of flavonoid-rich cocoa and chocolate,” Nutrition Research, vol. 24, no. 9, pp. 695–706, 2004. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Aviram, “Flavonoids-rich nutrients with potent antioxidant activity prevent atherosclerosis development: the licorice example,” International Congress Series, vol. 1262, pp. 320–327, 2004. View at Publisher · View at Google Scholar
  11. U. R. Desai, Cardiac glycosides. Virginia Commonwealth University School of Pharmacy, 2005.
  12. S. D. Langford and P. J. Boor, “Oleander toxicity: an examination of human and animal toxic exposures,” Toxicology, vol. 109, no. 1, pp. 1–13, 1996. View at Publisher · View at Google Scholar · View at Scopus
  13. P. K. Mazumder, P. V. Lakshmana Rao, D. Kumar, S. N. Dube, and S. Das Gupta, “Toxicological evaluation of Nerium oleander on isolated preparations,” Phytotherapy Research, vol. 8, no. 5, pp. 297–300, 1994. View at Google Scholar · View at Scopus
  14. K. Ding, J. N. Fang, T. Dong, K. W. Tsim, and H. Wu, “Characterization of a rhamnogalacturonan and a xyloglucan from neriumindicum and their activities on PC12 pheochromocytoma cells,” Journal of Natural Products, vol. 66, no. 1, pp. 7–10, 2003. View at Google Scholar
  15. V. Gupta and P. Mittal, “Phytochemical and Pharmacological Potential of Nerium oleander,” International Journal of Pharmaceutical Sciences and Research, vol. 1, pp. 3–5, 2010. View at Google Scholar
  16. M. M. Yassin and S. N. Mwafy, “Protective potential of glimepiride and Nerium oleander extract on lipid profile, body growth rate, and renal function in streptozotocin-induced diabetic rats,” Turkish Journal of Biology, vol. 31, no. 2, pp. 95–102, 2007. View at Google Scholar · View at Scopus
  17. N Turan, K. Akgün-Dar, S. E. Kuruca et al., “Cytotoxic effects of leaf, stem and root extracts of Nerium oleander on leukemia cell lines and role of the p-glycoprotein in this effect,” Journal of Experimental Therapeutics and Oncology, vol. 6, no. 1, pp. 31–38, 2006. View at Google Scholar
  18. N. Erdemoglu, E. Kupeli, and E. Yesilada, “Anti-inflammatory and antinociceptive activity assessment of plants used as remedy in Turkish folk medicine,” Journal of Ethnopharmacology, vol. 89, no. 1, pp. 123–129, 2003. View at Google Scholar
  19. M. S. Yu, S. W. Lai, K. F. Lin, J. N. Fang, W. H. Yuen, and R. C. Chang, “Characterization of polysaccharides from the flowers of Nerium indicum and their neuroprotective effects,” International Journal of Molecular Medicine, vol. 14, no. 5, pp. 917–924, 2004. View at Google Scholar
  20. M. S. Yu, A. Y. Wong, K. F. So, J. N. Fang, W. H. Yuen, and R. C. Chang, “New polysaccharide from Nerium indicum protects neurons via stress kinase signaling pathway,” Brain Research, vol. 1153, pp. 221–230, 2007. View at Google Scholar
  21. V. Gayathri, S. Ananthi, C. Chandronitha, M. K. Sangeetha, and H. R. Vasanthi, “Hypolipidemic potential of flowers of Nerium oleander in high fat diet-fed Sprague Dawley rats,” Natural Product Research, vol. 25, no. 11, pp. 1110–1114, 2011. View at Publisher · View at Google Scholar · View at Scopus
  22. V. Gayathri, S. Ananthi, C. Chandronitha, G. Ramakrishnan, R. L. Sundaram, and H. R. Vasanthi, “Cardioprotective effect of nerium oleander flower against isoproterenol-induced myocardial oxidative stress in experimental rats,” Journal of Cardiovascular Pharmacology and Therapeutics, vol. 16, no. 1, pp. 96–104, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. A. E. Nkengfack, A. G. B. Azebaze, A. K. Waffo, Z. T. Fomum, M. Meyer, and F. R. Van Heerden, “Cytotoxic isoflavones from Erythrina indica,” Phytochemistry, vol. 58, no. 7, pp. 1113–1120, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. D. J. Finney, Probit Analysis, Cambridge University Press, London, UK, 3rd edition, 1971.
  25. A. A. Van de Loosdrecht, R. H. Beelen, G. J. Ossenkoppele et al., “A tetrazolium-based colorimetric MTT assay to quantitate human monocyte mediated cytotoxicity against leukemic cells from cell lines and patients with acute myeloid leukemia,” Journal of Immunological Methods, vol. 174, no. 1-2, pp. 311–320, 1994. View at Google Scholar
  26. F. F. Safadi, J. Xu, S. L. Smock et al., “Expression of connective tissue growth factor in bone: Its role in osteoblast proliferation and differentiation in vitro and bone formation in vivo,” Journal of Cellular Physiology, vol. 196, no. 1, pp. 51–62, 2003. View at Publisher · View at Google Scholar
  27. A. P. Kourounakis, P. Victoratos, N. Peroulis et al., “Experimental hyperlipidemia and the effect of NSAIDs,” Experimental and Molecular Pathology, vol. 73, no. 2, pp. 135–138, 2002. View at Publisher · View at Google Scholar · View at Scopus
  28. K. A. Mitropoulos, G. J. Miller, D. J. Howarth, B. E. A. Reeves, and J. A. Cooper, “The effects of intravenous Triton WR-1339 on factor VII coagulant activity and plasma lipoproteins in normocholesterolaemic and hypercholesterolaemic rabbits,” Blood Coagulation and Fibrinolysis, vol. 5, no. 4, pp. 583–591, 1994. View at Google Scholar · View at Scopus
  29. H. Hayashi, S. Niinobe, Y. Matsumoto, and T. Suga, “Effects of Triton WR-1339 on lipoprotein lipolytic activity and lipid content of rat liver lysosomes,” Journal of Biochemistry, vol. 89, no. 2, pp. 573–579, 1981. View at Google Scholar · View at Scopus
  30. T. Mizui and M. Douteuchi, “Effect of polyamines on acidified ethanol-induced gastric lesions in rats,” Japanese Journal of Pharmacology, vol. 33, no. 5, pp. 939–945, 1983. View at Google Scholar
  31. W. T. Friedewald, R. I. Levy, and D. S. Fredrickson, “Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge,” Clinical Chemistry, vol. 18, no. 6, pp. 499–502, 1972. View at Google Scholar · View at Scopus
  32. B. Patwardhan, D. Warude, P. Pushpangadan, and N. Bhatt, “Ayurveda and traditional Chinese medicine: a comparative overview,” Evidence based Complementary and Alternative Medicine, vol. 2, pp. 465–473, 2005. View at Google Scholar
  33. P. Goldman, “Herbal medicines today and the roots of modern pharmacology,” Annals of Internal Medicine, vol. 135, no. 8, pp. 594–600, 2001. View at Google Scholar · View at Scopus
  34. B. M. Schmidt, D. M. Ribnicky, P. E. Lipsky et al., “Revisiting the ancient concept of botanical therapeutics,” Nature Chemical Biology, vol. 3, no. 7, pp. 360–365, 2007. View at Google Scholar
  35. T. H. Huang, B. P. Kota, and V. Razmovski, “Herbal or natural medicines as modulators of peroxisome proliferator-activated receptors and related nuclear receptors for therapy of metabolic syndrome,” Basic and Clinical Pharmacology and Toxicology, vol. 96, no. 1, pp. 13–14, 2005. View at Google Scholar
  36. R. O. Adome, J. W. Gachihi, B. Onegi, J. Tamale, and S. O. Apio, “The cardiotonic effect of the crude ethanolic extract of Nerium oleander in the isolated guinea pig hearts,” African Health Sciences, vol. 3, no. 2, pp. 77–82, 2003. View at Google Scholar · View at Scopus
  37. J. L. McLauglin, C. J. Chang, and D. Smith, “Simple bench-top bioassays (brine shrimp and potato discs) for the discovery of plant antitumour compounds,” in Human Medicinal Agents from Plants, A. D. Kinghorn and M. F. Balandrin, Eds., vol. 534 of ACS Symposium, pp. 112–137, American Chemical Society, Washington, DC, USA, 1993. View at Google Scholar
  38. S. Johansson, P. Lindholm, J. Gullbo, R. Larsson, L. Bohlin, and P. Claeson, “Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells,” Anti-Cancer Drugs, vol. 12, no. 5, pp. 475–483, 2001. View at Publisher · View at Google Scholar · View at Scopus
  39. A. Ghatak and O. P. Asthana, “Recent trends in hyperlipoproteinemias and its pharmacotherapy,” Indian Journal of Pharmacology, vol. 27, no. 1, pp. 14–29, 1995. View at Google Scholar · View at Scopus
  40. K. K. Ray and C. P. Cannon, “The potential relevance of the multiple lipid-independent (Pleiotropic) effects of statins in the management of acute coronary syndromes,” Journal of the American College of Cardiology, vol. 46, no. 8, pp. 1425–1433, 2005. View at Publisher · View at Google Scholar · View at Scopus
  41. G. Stanley, “Rapid increase in hepatic HMG CoA reductase activity and in vivo cholesterol synthesis after Triton WR 1339 injection,” Journal of Lipid Research, vol. 19, pp. 1450–1461, 1978. View at Google Scholar
  42. A. Souliman, H. Hicham, G. Dounia et al., “Vasorelaxant and anti-platelet aggregation effects of aqueous Ocimum basilicum extract,” Journal of Ethnopharmacology, vol. 125, no. 1, pp. 157–162, 2009. View at Publisher · View at Google Scholar · View at Scopus
  43. K. Yamamoto, B. Shen, C. Zarins, and A. M. Scanu, “In vitro and in vivo interactions of Triton 1339 with plasma lipoproteins of normolipidemic rhesus monkeys. Preferential effects on high density lipoproteins,” Arteriosclerosis, vol. 4, no. 4, pp. 418–434, 1984. View at Google Scholar · View at Scopus
  44. S. Sudheesh, G. Presannakumar, S. Vijayakumar, and N. R. Vijayalakshmi, “Hypolipidemic effect of flavonoids from Solanum melongena,” Plant Foods for Human Nutrition, vol. 51, no. 4, pp. 321–330, 1997. View at Publisher · View at Google Scholar · View at Scopus
  45. S. M. Grundy, “Cholesterol and coronary heart disease. A new era,” Journal of the American Medical Association, vol. 256, no. 20, pp. 2849–2858, 1986. View at Google Scholar · View at Scopus
  46. P. M. Kris-Etherton, K. D. Hecker, A. Bonanome et al., “Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer,” American Journal of Medicine, vol. 113, supplement 9, pp. 71S–88S, 2002. View at Google Scholar · View at Scopus