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Journal of Chemistry
Volume 2013, Article ID 840954, 8 pages
Research Article

Nano-ZnO Catalyzed Green and Efficient One-Pot Four-Component Synthesis of Pyranopyrazoles

1Department of Chemistry, Shri Muktanand College, Gangapur, Maharashtra 431 109, India
2Department of Chemistry, Deogiri College, Station Road, Aurangabad, Maharashtra 431 005, India

Received 15 May 2013; Accepted 29 June 2013

Academic Editor: Hakan Arslan

Copyright © 2013 Sunil U. Tekale et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


An efficient zinc oxide nanoparticle catalyzed one-pot, four-component synthesis of 6-amino-3-methyl-5-cyano-4-aryl-1,4-dihydropyrano[2,3-c]pyrazoles from aromatic aldehyde, malononitrile, ethyl acetoacetate, and hydrazine hydrate in aqueous medium is described. Since water was employed as the reaction medium, it serves as a green route for the synthesis of pyrano[2,3-c]pyrazoles. The advantages associated with the present protocol include nonchromatographic purification technique, use of recyclable heterogeneous nano-ZnO catalyst in aqueous medium, and short reaction time. It combines successfully the synergistic effect of green chemistry with nanocatalysis.