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Journal of Chemistry
Volume 2013, Article ID 890617, 8 pages
Research Article

Synthesis and Antimicrobial Activities of Some New Heterocyclic Compounds Based on 6-Chloropyridazine-3(2H)-thione

1Riyadh Community College, King Saud University, P.O. Box 28095, Riyadh 11437, Saudi Arabia
2Chemistry Department, Faculty of Science, Jazan University, P.O. Box 2079, Jazan, Saudi Arabia
3Chemistry Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt
4Chemical Engineering Department, College of Engineering, King Saud University, P.O. Box 800, Riyadh 11421, Saudi Arabia

Received 21 January 2013; Revised 27 February 2013; Accepted 28 February 2013

Academic Editor: Patricia Valentao

Copyright © 2013 Nasser M. Abd El-Salam et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Three tricyclic ring system, pyridazino[6,1-b]quinazolin-10-ones, benzimidazolo-pyridazine thione, and 1,2,4-benzotriazino-pyridazinethione along with imidazo-[1,2-b]-pyridazinethione, 1,2,4-triazolo[4,3-b]pyridazine-thione derivatives were synthesized starting from 6-chloropyridazin3-(2H)-thione. Some disulfide and sulfide derivatives were also prepared. The antimicrobial activity of the synthesized compounds was tested. Some of these compounds possess a highly response against gram-positive and gram-negative bacteria as well as fungi.