Synthesis and Antimicrobial Activities of Some New Heterocyclic Compounds Based on 6-Chloropyridazine-3(2H)-thione

Table 2

Physical properties of the prepared compounds (2–13).

Compd. no.	m.p. °C	Yield (%)	Solvent of cryst.	Mol. formula (M.wt)	Elemental analysis; Calcd./Found
					C	H	N	S
2a	182–184	37	Ethanol	C11H7N3OS	57.61	3.10	18.35	13.99
				229.26	57.63	3.08	18.33	13.98
2b	255–257	41	Methanol	C11H5Br2N3OS	34.16	1.33	10.89	8.30
				387.05	34.14	1.30	10.86	8.28
2c	232–234	45	Ethanol	C11H6BrN3OS	42.91	1.98	13.68	10.42
				308.15	42.88	1.96	13.64	10.40
3	168–170	49	Methanol	C10H7N3S	59.70	3.56	20.92	15.96
				201.25	59.68	3.51	20.88	15.93
4	285–287	39	Acetic acid	C10H8N4S	55.56	3.92	25.95	14.92
				216.26	55.54	3.73	25.91	14.82
5	282-283	61	Ethanol	C13H11N3OS	60.58	4.78	16.38	12.49
				257.06	60.68	4.31	16.33	12.46
6	279-280	58	Ethanol	C5H5N5S	35.94	3.07	41.92	19.20
				167.19	35.92	3.01	41.89	19.18
7a	261–263	52	Ethanol	C11H7ClN4S	50.33	2.71	21.37	12.24
				262.72	50.29	2.69	21.33	12.20
7b	242-243	63	Ethanol	C11H8N4S	57.85	3.55	24.56	14.07
				228.27	57.88	3.53	24.54	14.04
8a	271–273	35	Methanol	C12H12N4S	59.02	4.99	22.97	13.10
				244.31	58.99	4.95	22.93	13.12
8b	246–248	44	Methanol	C12H11N5O2S	49.78	3.86	24.23	11.12
				289.31	49.82	3.83	24.21	11.08
9	205–207	49	Ethanol	C11H10N4OS2	47.52	3.57	20.17	23.09
				278.35	47.47	3.62	20.13	23.04
10	239-240	73	Methanol	C10H5ClN4O4S2	34.86	1.62	16.29	18.63
				344.75	34.84	1.46	16.25	18.60
11	221–223	85	ether 60–80/Benzene	C8H4Cl2N4S2	33.04	1.42	19.25	22.09
				291.17	33.00	1.38	19.24	22.02
12	234–236	73	Ethanol	C10H8N2S3	47.64	3.25	11.14	38.15
				252.37	47.59	3.20	11.10	38.11
13	186–88	71	Methanol	C8H4Cl2N4S	37.10	1.59	21.65	12.40
				259.11	37.08	1.56	21.62	12.37