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Journal of Chemistry
Volume 2013, Article ID 916960, 5 pages
Research Article

Iodine-Mediated Neutral and Selective N-Boc Deprotection

1Department of Chemistry, Acharya Nagarjuna University, Guntur, Andhra Pradesh 522510, India
2Dr. Reddy's Institute of Life Science, University of Hyderabad Campus, Hyderabad 500046, India
3Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh 521001, India

Received 6 May 2013; Accepted 17 June 2013

Academic Editor: Hakan Arslan

Copyright © 2013 G. Pavan Kumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A simple, efficient, and alternative method has been developed for the N-Boc deprotection of structurally diverse protected amines. Selective removal of N-Boc groups was achieved with excellent yields under a solvent-free condition or in a solvent using iodine as a catalyst. The methodology involving the first use of iodine for N-Boc deprotection of protected amines represents an effective and useful alternative to the previously reported methods.