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Journal of Chemistry
Volume 2013, Article ID 920719, 8 pages
Research Article

A Practical Catalyst-Free Synthesis of 6-Amino-4 Alkyl/Aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-carbonitrile in Aqueous Medium

Department of Chemistry, North Eastern Hill University, Shillong 793022, India

Received 25 June 2012; Accepted 30 July 2012

Academic Editor: John CG Zhao

Copyright © 2013 Manisha Bihani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A completely green and improved method for the synthesis of 6-amino-4-aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-carbonitriles by a four-component reaction of a mixture of ethyl acetoacetate, hydrazine hydrate, aldehyde, and malononitrile in boiling water is reported. Similar synthesis starting from aliphatic aldehydes was carried out in water: ethanol (1 : 1) at reflux temperature without using any catalyst.